Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage
Matthias Merker, Camille Blin, Stefano Mona, Nicolas Duforet-Frebourg, Sophie Lecher, Eve Willery, Michael G B Blum, Sabine Rüsch-Gerdes, Igor Mokrousov, Eman Aleksic, Caroline Allix-Béguec, Annick Antierens, Ewa Augustynowicz-Kopeć, Marie Ballif, Francesca Barletta, Hans Peter Beck, Clifton E Barry III, Maryline Bonnet, Emanuele Borroni, Isolina Campos-Herrero, Daniela Cirillo, Helen Cox, Suzanne Crowe, Valeriu Crudu, Roland Diel et al.
Nature Genetics 47, 242–249 (2015) doi:10.1038/ng.3195
Received 21 July 2014 Accepted 19 December 2014 Published online 19 January 2015 Corrected online 10 February 2015
Abstract
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
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'생물 연구 > 자료실' 카테고리의 다른 글
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